Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with <i>Mycobacterium tuberculosis</i>
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- Norbert Reiling
- *Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;
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- Christoph Hölscher
- *Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;
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- Alexandra Fehrenbach
- *Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;
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- Svenja Kröger
- *Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;
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- Carsten J. Kirschning
- †Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany; and
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- Sanna Goyert
- ‡Division of Molecular Medicine, Cornell University Medical College, Manhasset, NY 11030
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- Stefan Ehlers
- *Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany;
説明
<jats:title>Abstract</jats:title> <jats:p>Innate resistance against Mycobacterium tuberculosis is thought to depend critically on engagement of pattern recognition receptors on macrophages. However, the relative contribution of these receptors for containing M. tuberculosis infection has remained unexplored in vivo. To address this issue, we infected mice defective in CD14, TLR2, or TLR4 with M. tuberculosis by aerosol. Following infection with 100 mycobacteria, either mutant strain was as resistant as congenic control mice. Granuloma formation, macrophage activation, and secretion of proinflammatory cytokines in response to low-dose aerosol infection were identical in mutant and control mice. However, high-dose aerosol challenge with 2000 CFU M. tuberculosis revealed TLR2-, but not TLR4-defective mice to be more susceptible than control mice. In conclusion, while TLR2 signaling contributes to innate resistance against M. tuberculosis in borderline situations, its function, and that of CD14 and TLR4, in initiating protective responses against naturally low-dose airborne infection is redundant.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 169 (7), 3480-3484, 2002-10-01
The American Association of Immunologists