Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation
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- Jikui Song
- Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
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- Olga Rechkoblit
- Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
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- Timothy H. Bestor
- Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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- Dinshaw J. Patel
- Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
説明
<jats:p>The eukaryote maintenance DNA methyltransferase discriminates against de novo CpG methylation sites.</jats:p>
収録刊行物
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- Science
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Science 331 (6020), 1036-1040, 2011-02-25
American Association for the Advancement of Science (AAAS)