Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

DOI Web Site 被引用文献15件
  • Karsten Fischer
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Emmanuel Scotet
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Marcus Niemeyer
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Heidrun Koebernick
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Jens Zerrahn
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Sophie Maillet
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Robert Hurwitz
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Mischo Kursar
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Marc Bonneville
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Stefan H. E. Kaufmann
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France
  • Ulrich E. Schaible
    Department of Immunology and Core Facility of Protein Chemistry, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany; and Institut de Biologie, Institut National de la Santé et de la Recherche Médicale U463, 44035 Nantes, France

抄録

<jats:p>A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-γ production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.</jats:p>

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