Downregulation of ephrin-B1 is a critical event of podocyte injury

DOI オープンアクセス
  • Yoshiyasu Fukusumi
    Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Veniamin Ivanov
    Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Ying Zhang
    Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Hidenori Yasuda
    Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Hiroshi Kawachi
    Department of Cell Biology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Japan

説明

<jats:p>Proteinuria in several glomerular diseases results from dysfunction of the slit diaphragm, a cell-cell junction of glomerular epithelial cells (podocytes). Ephrin-B1 and its related molecule NHERF 2 are novel essential components of the slit diaphragm. Ephrin-B1 interacts with nephrin via the extra-cellular domain and interacts with NHERF2 via the cytoplasmic site. In the proteinuric state induced by the stimulation to nephrin, nephrin and ephrin-B1 are phosphorylated, and NHERF2 is de- phosphorylated and consequent disruption of the linkage and downregulation of nephrin, ephrin-B1 and NHERF2 are a critical pathogenic event of podocyte injury. Keywords: Podocyte; Slit Diaphragm; Ephrin-B1; Nephrin; NHERF2</jats:p>

収録刊行物

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

  • CRID
    1360294643765392128
  • DOI
    10.36811/cjn.2021.110004
  • 資料種別
    journal article
  • データソース種別
    • Crossref
    • KAKEN
    • OpenAIRE

問題の指摘

ページトップへ