Two StAR-related lipid transfer proteins play specific roles in endocytosis, exocytosis, and motility in the parasitic protist Entamoeba histolytica
説明
<jats:p>Lipid transfer proteins (LTPs) are the key contributor of organelle-specific lipid distribution and cellular lipid homeostasis. Here, we report a novel implication of LTPs in phagocytosis, trogocytosis, pinocytosis, biosynthetic secretion, recycling of pinosomes, and motility of the parasitic protist <jats:italic>E</jats:italic>. <jats:italic>histolytica</jats:italic>, the etiological agent of human amoebiasis. We show that two StAR-related lipid transfer (START) domain-containing LTPs (named as EhLTP1 and 3) are involved in these biological pathways in an LTP-specific manner. Our findings provide novel implications of LTPs, which are relevant to the elucidation of pathophysiology of the diseases caused by parasitic protists.</jats:p>
収録刊行物
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- PLOS Pathogens
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PLOS Pathogens 17 (4), e1009551-, 2021-04-28
Public Library of Science (PLoS)
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キーワード
- Entamoebiasis
- Organisms, Genetically Modified
- QH301-705.5
- Entamoeba histolytica
- Membrane Transport Proteins
- CHO Cells
- RC581-607
- Phosphoproteins
- Endocytosis
- Exocytosis
- Cricetulus
- Phagocytosis
- Cell Movement
- Animals
- Immunologic diseases. Allergy
- Biology (General)
- Carrier Proteins
- Metabolic Networks and Pathways
詳細情報 詳細情報について
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- CRID
- 1360294643842594176
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- ISSN
- 15537374
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- PubMed
- 33909710
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
