Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains

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  • Van Tran
    Saints-Pères Paris Institute for the Neurosciences, CNRS, Université de Paris, F-75006 Paris, France
  • Takafumi Miki
    Graduate School of Brain Science, Doshisha University, Kyotanabe-shi, Kyoto 610-0394, Japan
  • Alain Marty
    Saints-Pères Paris Institute for the Neurosciences, CNRS, Université de Paris, F-75006 Paris, France

説明

<jats:title>Significance</jats:title> <jats:p>Short-term changes in the strength of synaptic connections underlie many brain functions. The strength of a synapse in response to subsequent stimulation is largely determined by the remaining number of synaptic vesicles available for release. We developed a methodological approach to measure the dynamics of various vesicle pools following synaptic activity. We find that the readily releasable pool, which comprises vesicles that are docked or tethered to release sites, is fed by a small-sized pool containing approximately one to four vesicles per release site at rest. This upstream pool is significantly depleted even after a short stimulation train. Therefore, regulation of the size of the upstream pool emerges as a key factor in determining synaptic strength during and after sustained stimulation.</jats:p>

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