Chronic tissue inflammation and metabolic disease
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説明
<jats:p>Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic dysfunction in obesity. Here, we summarize recent advances in our understanding of immunometabolism. We discuss the characteristics of chronic inflammation in the major metabolic tissues and how obesity triggers these events, including a focus on the role of adipose tissue hypoxia and macrophage-derived exosomes. Last, we also review current and potential new therapeutic strategies based on immunomodulation.</jats:p>
収録刊行物
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- Genes & Development
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Genes & Development 35 (5-6), 307-328, 2021-03-01
Cold Spring Harbor Laboratory
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キーワード
- immunometabolism
- metaflammation
- macrophage
- Cardiovascular
- Exosomes
- Medical and Health Sciences
- β-cell dysfunction
- Immunomodulation
- metaflammation br
- Metabolic Diseases
- insulin resistance
- 2.1 Biological and endogenous factors
- Humans
- Obesity
- Aetiology
- Metabolic and endocrine
- Nutrition
- Inflammation
- β
- Diabetes
- Psychology and Cognitive Sciences
- Biological Sciences
- -cell dysfunction br
- Cell Hypoxia
- glucose intolerance
- Adipose Tissue
- inflammation
- Chronic Disease
- Developmental Biology
詳細情報 詳細情報について
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- CRID
- 1360294645172665728
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- ISSN
- 15495477
- 08909369
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- PubMed
- 33649162
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- データソース種別
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- Crossref
- OpenAIRE