The Impact of Chemotherapy on the Ovaries: Molecular Aspects and the Prevention of Ovarian Damage

DOI Web Site 被引用文献1件
  • Charlotte Sonigo
    Department of Reproductive Medicine and Fertility Preservation, Hôpital Antoine Béclère, 92140 Clamart, France
  • Isabelle Beau
    Inserm U1185 Université Paris-Sud, Université Paris Saclay, 94276 Le Kremlin Bicêtre, France
  • Nadine Binart
    Inserm U1185 Université Paris-Sud, Université Paris Saclay, 94276 Le Kremlin Bicêtre, France
  • Michaël Grynberg
    Department of Reproductive Medicine and Fertility Preservation, Hôpital Antoine Béclère, 92140 Clamart, France

書誌事項

公開日
2019-10-27
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.3390/ijms20215342
公開者
MDPI AG

説明

<jats:p>Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and subsequent infertility. In order to protect gametes from the gonadotoxic effects of chemotherapy, several fertility preservation techniques—such as oocyte or embryo cryopreservation with or without ovarian stimulation, or cryopreservation of the ovarian cortex—should be considered. However, these methods may be difficult to perform, and the future use of cryopreserved germ cells remains uncertain. Therefore, improving the methods currently available and developing new strategies to preserve fertility represent major challenges in the area of oncofertility. Animal and ovarian culture models have been used to decipher the effects of different cytotoxic agents on ovarian function and several theories regarding chemotherapy gonadotoxicity have been raised. For example, cytotoxic agents might (i) have a direct detrimental effect on the DNA of primordial follicles constituting the ovarian reserve and induce apoptosis; (ii) induce a massive growth of dormant follicles, which are then destroyed; or (ii) induce vascular ovarian damage. Thanks to improvements in the understanding of the mechanisms involved, a large number of studies have been carried out to develop molecules limiting the negative impact of chemotherapy on the ovaries.</jats:p>

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