Cutting Edge: Nrf2 Regulates Neutrophil Recruitment and Accumulation in Skin during Contact Hypersensitivity

DOI PDF 被引用文献6件
  • Doumet Georges Helou
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,
  • Benoît Noël
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,
  • Françoise Gaudin
    US31-UMS3679, La Plateforme d'Histologie sous Immunopathologie de Clamart, Institut Paris-Saclay d’Innovation Thérapeutique , Clamart 92140 ,
  • Hervé Groux
    Immunosearch , Grasse 06120 ,
  • Zeina El Ali
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,
  • Marc Pallardy
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,
  • Sylvie Chollet-Martin
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,
  • Saadia Kerdine-Römer
    Inflammation, Chimiokines et Immunopathologie, INSERM UMR996, Université Paris-Sud, Université Paris-Saclay , Châtenay-Malabry 92296 ,

この論文をさがす

説明

<jats:title>Abstract</jats:title> <jats:p>Neutrophils are essential during contact hypersensitivity (CHS), a common skin allergic disease. NF-E2–related factor-2 (Nrf2) is a key regulator of redox balance and skin homeostasis playing a protective role in CHS. In this study, we investigated Nrf2 role in neutrophil recruitment during the sensitization phase of CHS. Comparing wild-type and Nrf2 knockout mice, we demonstrated that Nrf2 regulated dinitrochlorobenzene-induced xenoinflammation, notably neutrophil recruitment to sensitized skin. Nrf2 protective role was associated with high expression of antioxidant genes (ho-1, gclc, nqo1…) and decreased chemokine production (CCL2, CCL4, CCL11). Interestingly, skin sensitization induced CD36 upregulation in skin-resident macrophages. In vitro results confirmed that the transcription of cd36 gene in macrophages was dependent on Nrf2 and led to an improved capacity to phagocyte-damaged neutrophils by efferocytosis. Nrf2 emerges as a critical target in the sensitization phase of CHS regulating neutrophil recruitment and accumulation in the skin through antioxidant-dependent and -independent mechanisms.</jats:p>

収録刊行物

被引用文献 (6)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ