Prime and target immunization protects against liver-stage malaria in mice

Anita Gola, Daniel Silman, Adam A. Walters, Saranya Sridhar, Stefan Uderhardt, Ahmed M. Salman, Benedict R. Halbroth, Duncan Bellamy, Georgina Bowyer, Jonathan Powlson, Megan Baker, Navin Venkatraman, Ian Poulton, Eleanor Berrie, Rachel Roberts, Alison M. Lawrie, Brian Angus, Shahid M. Khan, Chris J. Janse, Katie J. Ewer, Ronald N. Germain, Alexandra J. Spencer, Adrian V. S. Hill

doi:10.1126/scitranslmed.aap9128

Prime and target immunization protects against liver-stage malaria in mice

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Anita Gola

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Daniel Silman

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Adam A. Walters

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Saranya Sridhar

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Stefan Uderhardt

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ahmed M. Salman

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Benedict R. Halbroth

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Duncan Bellamy

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Georgina Bowyer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Jonathan Powlson

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Megan Baker

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Navin Venkatraman

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Ian Poulton

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Eleanor Berrie

Clinical Biomanufacturing Facility, University of Oxford, Churchill Hospital, Oxford OX3 7JT, UK.
Rachel Roberts

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Alison M. Lawrie

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Brian Angus

Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Shahid M. Khan

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Chris J. Janse

Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Katie J. Ewer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Ronald N. Germain

Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Alexandra J. Spencer

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Adrian V. S. Hill

Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

抄録

<jats:p>A prime and target vaccine for liver-stage malaria results in sterile protection in mouse disease models and appears safe for human use.</jats:p>