Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Multicenter, Double-Blind, Randomized, Placebo-controlled Trial

  • Roham T. Zamanian
    Division of Pulmonary, Allergy, and Critical Care Medicine and
  • David Badesch
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado;
  • Lorinda Chung
    Division of Pulmonary, Allergy, and Critical Care Medicine and
  • Robyn T. Domsic
    Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Thomas Medsger
    Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Ashley Pinckney
    Rho Federal Systems Division, Durham, North Carolina;
  • Lynette Keyes-Elstein
    Rho Federal Systems Division, Durham, North Carolina;
  • Carla D’Aveta
    Rho Federal Systems Division, Durham, North Carolina;
  • Meagan Spychala
    Rho Federal Systems Division, Durham, North Carolina;
  • R. James White
    Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, New York;
  • Paul M. Hassoun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland;
  • Fernando Torres
    Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern, Dallas, Texas;
  • Andrew J. Sweatt
    Division of Pulmonary, Allergy, and Critical Care Medicine and
  • Jerry A. Molitor
    Division of Rheumatic and Autoimmune Diseases, University of Minnesota, Minneapolis, Minnesota;
  • Dinesh Khanna
    Division of Rheumatology, University of Michigan, Ann Arbor, Michigan;
  • Holden Maecker
    Division of Pulmonary, Allergy, and Critical Care Medicine and
  • Beverly Welch
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; and
  • Ellen Goldmuntz
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; and
  • Mark R. Nicolls
    Division of Pulmonary, Allergy, and Critical Care Medicine and

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