The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations
-
- Raul Zamora-Ros
- Medical Research Council, Epidemiology Unit, Cambridge, U.K.
-
- Nita G. Forouhi
- Medical Research Council, Epidemiology Unit, Cambridge, U.K.
-
- Stephen J. Sharp
- Medical Research Council, Epidemiology Unit, Cambridge, U.K.
-
- Carlos A. González
- Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Barcelona, Spain
-
- Brian Buijsse
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
-
- Marcela Guevara
- Navarre Public Health Institute, Pamplona, Spain
-
- Yvonne T. van der Schouw
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
-
- Pilar Amiano
- CIBER Epidemiología y Salud Pública, Madrid, Spain
-
- Heiner Boeing
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
-
- Lea Bredsdorff
- National Food Institute, Technical University of Denmark, Moerkhoej, Denmark
-
- Françoise Clavel-Chapelon
- INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health, Villejuif, France
-
- Guy Fagherazzi
- INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health, Villejuif, France
-
- Edith J. Feskens
- Division of Human Nutrition, Section of Nutrition and Epidemiology, University of Wageningen, Wageningen, the Netherlands
-
- Paul W. Franks
- Genetic and Molecular Epidemiology Unit, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden
-
- Sara Grioni
- Nutritional Epidemiology Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy
-
- Verena Katzke
- Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
-
- Timothy J. Key
- Cancer Epidemiology Unit, University of Oxford, Oxford, U.K.
-
- Kay-Tee Khaw
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, U.K.
-
- Tilman Kühn
- Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
-
- Giovanna Masala
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy
-
- Amalia Mattiello
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
-
- Esther Molina-Montes
- CIBER Epidemiología y Salud Pública, Madrid, Spain
-
- Peter M. Nilsson
- Department of Clinical Sciences, Lund University, Malmö, Sweden
-
- Kim Overvad
- Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
-
- Florence Perquier
- INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health, Villejuif, France
-
- J. Ramón Quirós
- Public Health Directorate, Asturias, Spain
-
- Isabelle Romieu
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
-
- Carlotta Sacerdote
- Center for Cancer Prevention in Piemonte, and Human Genetic Foundation, Torino, Italy
-
- Augustin Scalbert
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
-
- Matthias Schulze
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
-
- Nadia Slimani
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
-
- Annemieke M.W. Spijkerman
- National Institute for Public Health and the Environment, Bilthoven, the Netherlands
-
- Anne Tjonneland
- Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
-
- Maria Jose Tormo
- CIBER Epidemiología y Salud Pública, Madrid, Spain
-
- Rosario Tumino
- Cancer Registry and Histopathology Unit, “Civile M.P. Arezzo” Hospital, ASP Ragusa, Italy
-
- Daphne L. van der A
- Epidemiology Department, Murcia Regional Health Council, Murcia, Spain
-
- Claudia Langenberg
- Medical Research Council, Epidemiology Unit, Cambridge, U.K.
-
- Elio Riboli
- School of Public Health, Imperial College, London, U.K.
-
- Nicholas J. Wareham
- Medical Research Council, Epidemiology Unit, Cambridge, U.K.
抄録
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participants with 3.99 million person-years of follow-up in eight European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the Phenol-Explorer, the U.K. Food Standards Agency, and the U.S. Department of Agriculture databases. Hazard ratios (HRs) from country-specific Prentice-weighted Cox regression models were pooled using random-effects meta-analysis.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>In multivariable models, a trend for an inverse association between total flavonoid intake and type 2 diabetes was observed (HR for the highest vs. the lowest quintile, 0.90 [95% CI 0.77–1.04]; P valuetrend = 0.040), but not with lignans (HR 0.88 [95% CI 0.72–1.07]; P valuetrend = 0.119). Among flavonoid subclasses, flavonols (HR 0.81 [95% CI 0.69–0.95]; P valuetrend = 0.020) and flavanols (HR 0.82 [95% CI 0.68–0.99]; P valuetrend = 0.012), including flavan-3-ol monomers (HR 0.73 [95% CI 0.57–0.93]; P valuetrend = 0.029), were associated with a significantly reduced hazard of diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Prospective findings in this large European cohort demonstrate inverse associations between flavonoids, particularly flavanols and flavonols, and incident type 2 diabetes. This suggests a potential protective role of eating a diet rich in flavonoids, a dietary pattern based on plant-based foods, in the prevention of type 2 diabetes.</jats:p> </jats:sec>
収録刊行物
-
- Diabetes Care
-
Diabetes Care 36 (12), 3961-3970, 2013-11-13
American Diabetes Association