Electron induced single strand break and cyclization: a DFT study on the radiosensitization mechanism of the nucleotide of 8-bromoguanine
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- Lidia Chomicz
- Department of Chemistry
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- Al'ona Furmanchuk
- Interdisciplinary Nanotoxicity Center
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- Jerzy Leszczynski
- Interdisciplinary Nanotoxicity Center
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- Janusz Rak
- Department of Chemistry
説明
<p>The radiosensitization mechanism of 8-bromoguanosine is studied on its 3′,5′-diphosphate. Electron attachment to the nucleotide results in phosphodiester bond breakage or the 5′,8-cycloguanosine lesion.</p>
収録刊行物
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- Phys. Chem. Chem. Phys.
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Phys. Chem. Chem. Phys. 16 (14), 6568-6574, 2014
Royal Society of Chemistry (RSC)