Partial‐volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia

  • Yasser Alemán‐Gómez
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Elena Najdenovska
    Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Timo Roine
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Mário João Fartaria
    Medical Image Analysis Laboratory (MIAL) Centre d'Imagerie BioMédicale (CIBM) Switzerland
  • Erick J. Canales‐Rodríguez
    Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Zita Rovó
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Patric Hagmann
    Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Philippe Conus
    Service of General Psychiatry, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Kim Q. Do
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Paul Klauser
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Pascal Steullet
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Philipp S. Baumann
    Center for Psychiatric Neuroscience, Department of Psychiatry Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland
  • Meritxell Bach Cuadra
    Department of Radiology Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Lausanne Switzerland

抄録

<jats:title>Abstract</jats:title><jats:p>The structural complexity of the thalamus, due to its mixed composition of gray and white matter, make it challenging to disjoint and quantify each tissue contribution to the thalamic anatomy. This work promotes the use of partial‐volume‐based over probabilistic‐based tissue segmentation approaches to better capture thalamic gray matter differences between patients at different stages of psychosis (early and chronic) and healthy controls. The study was performed on a cohort of 23 patients with schizophrenia, 41 with early psychosis and 69 age and sex‐matched healthy subjects. Six tissue segmentation approaches were employed to obtain the gray matter concentration/probability images. The statistical tests were applied at three different anatomical scales: whole thalamus, thalamic subregions and voxel‐wise. The results suggest that the partial volume model estimation of gray matter is more sensitive to detect atrophies within the thalamus of patients with psychosis. However all the methods detected gray matter deficit in the pulvinar, particularly in early stages of psychosis. This study demonstrates also that the gray matter decrease varies nonlinearly with age and between nuclei. While a gray matter loss was found in the pulvinar of patients in both stages of psychosis, reduced gray matter in the mediodorsal was only observed in early psychosis subjects. Finally, our analyses point to alterations in a sub‐region comprising the lateral posterior and ventral posterior nuclei. The obtained results reinforce the hypothesis that thalamic gray matter assessment is more reliable when the tissues segmentation method takes into account the partial volume effect.</jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ