説明
<jats:p> The resistance of the action potential to ischemic inactivation observed in diabetic patients has been reproduced in vivo in rat rendered diabetic with streptozotocin and, acutely, in normal rats given p.o. a load of glucose. The resistance phenomenon was not detected in galactosemic rats. The preservation of the action potential was reversed by the administration of insulin, but not by treatment with an aldose reductase (AR) inhibitor. The ischemic resistance is attributed to the metabolic availability of excess glucose to the nerve. AR does not appear to be involved in the phenomenon. </jats:p>
収録刊行物
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- Canadian Journal of Physiology and Pharmacology
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Canadian Journal of Physiology and Pharmacology 63 (7), 773-777, 1985-07-01
Canadian Science Publishing
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詳細情報 詳細情報について
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- CRID
- 1360294646889470080
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- DOI
- 10.1139/y85-128
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- ISSN
- 12057541
- 00084212
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- データソース種別
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- Crossref