Structure of the human insulin receptor gene and characterization of its promoter.

DOI Web Site 被引用文献5件
  • S Seino
    Howard Hughes Medical Institute, Chicago, IL 60637.
  • M Seino
    Howard Hughes Medical Institute, Chicago, IL 60637.
  • S Nishi
    Howard Hughes Medical Institute, Chicago, IL 60637.
  • G I Bell
    Howard Hughes Medical Institute, Chicago, IL 60637.

書誌事項

公開日
1989-01
DOI
  • 10.1073/pnas.86.1.114
公開者
Proceedings of the National Academy of Sciences

この論文をさがす

説明

<jats:p>The human insulin receptor gene, INSR, and its promoter region have been isolated and characterized. The gene spans greater than 120 kilobase pairs (kbp) and has 22 exons. All introns interrupt protein coding regions of the gene. The 11 exons encoding the alpha subunit of the receptor are dispersed over greater than 90 kbp, whereas the 11 exons encoding the beta subunit are located together in a region of approximately 30 kbp. Three transcriptional initiation sites have been identified and are located 276, 282, and 283 bp upstream of the translation initiation site. In addition, a 247-bp fragment from the promoter region possessing 62.6% of the maximal promoter activity has been identified. This promoter-active fragment lacks a TATA-like sequence but has two possible binding regions for the transcriptional factor Sp1. Comparison of the exon structure of the tyrosine kinase domain of the INSR with the corresponding regions of the human SRC, ROS, and ERBB2 (NGL) protooncogenes indicates that the exon-intron organization of this region has not been well conserved.</jats:p>

収録刊行物

被引用文献 (5)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ