Animal models of pulmonary hypertension: Getting to the heart of the problem

DOI Web Site Web Site Web Site 被引用文献1件
  • Joshua P. Dignam
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK
  • Tara E. Scott
    Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute Monash University Clayton Campus Clayton Victoria Australia
  • Barbara K. Kemp‐Harper
    Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute Monash University Clayton Campus Clayton Victoria Australia
  • Adrian J. Hobbs
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

説明

<jats:sec><jats:label /><jats:p>Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease due to the development of right ventricular (RV) failure. At present, no treatments targeted at the right ventricle are available, and RV function is not widely considered in the preclinical assessment of new therapeutics. Several small animal models are used in the study of PH, including the classic models of exposure to either hypoxia or monocrotaline, newer combinational and genetic models, and pulmonary artery banding, a surgical model of pure RV pressure overload. These models reproduce selected features of the structural remodelling and functional decline seen in patients and have provided valuable insight into the pathophysiology of RV failure. However, significant reversal of remodelling and improvement in RV function remains a therapeutic obstacle. Emerging animal models will provide a deeper understanding of the mechanisms governing the transition from adaptive remodelling to a failing right ventricle, aiding the hunt for druggable molecular targets.</jats:p></jats:sec><jats:sec><jats:title>LINKED ARTICLES</jats:title><jats:p>This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc</jats:ext-link></jats:p></jats:sec>

収録刊行物

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ