Efficient and Robust <i>Paramyxoviridae</i> Reverse Genetics Systems

DOI Web Site 2 Citations
  • Shannon M. Beaty
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Arnold Park
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Sohui T. Won
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Patrick Hong
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Michael Lyons
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
  • Frederic Vigant
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Alexander N. Freiberg
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
  • Benjamin R. tenOever
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • W. Paul Duprex
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA
  • Benhur Lee
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Christina F. Spiropoulou
    editor

Description

<jats:p>The ability to manipulate the genome of paramyxoviruses and evaluate the effects of these changes at the phenotypic level is a powerful tool for the investigation of specific aspects of the viral life cycle and viral pathogenesis. However, reverse genetics systems for paramyxoviruses are notoriously inefficient, when successful. The ability to efficiently and robustly rescue paramyxovirus reverse genetics systems can be used to answer basic questions about the biology of paramyxoviruses, as well as to facilitate the considerable translational efforts being devoted to developing live attenuated paramyxovirus vaccine vectors.</jats:p>

Journal

  • mSphere

    mSphere 2 (2), 2017-04-26

    American Society for Microbiology

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