Gorham-Stout Disease Management during Pregnancy

  • Elena Bargagli
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Caterina Piccioli
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Edoardo Cavigli
    Department of Radiodiagnostic and Emergency, Careggi University Hospital, Florence, Italy
  • Marianna Scola
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Elisabetta Rosi
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Federico Lavorini
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Luca Novelli
    Department of Pathology, Careggi University Hospital, Florence, Italy
  • Dario Ugolini
    Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy
  • Tommaso Notaristefano
    Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy
  • Pieralli Filippo
    Subintentive Medicine Section, Careggi University Hospital, Florence, Italy
  • Vittorio Miele
    Department of Radiodiagnostic and Emergency, Careggi University Hospital, Florence, Italy
  • Camilla Comin
    Department of Pathology, Careggi University Hospital, Florence, Italy
  • Massimo Pistolesi
    Department of Clinical and Experimental Biomedical Sciences, Careggi University Hospital, Florence, Italy
  • Luca Voltolini
    Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy

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<jats:title>Abstract</jats:title><jats:p>Gorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. Chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. Extrapulmonary alterations may include chylous ascites, lymphopenia, and destructing bone disease for overgrowth of lymphatic vessels. Here, we report the case of a young woman who developed a severe and recalcitrant GSD with persistent unilateral chylothorax during pregnancy. The complex management of this patient during and after pregnancy was discussed and compared with literature data to contribute to the definition of a correct diagnostic and therapeutic approach to this rare lymphatic disease.</jats:p>

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