The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility

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  • Rasmus Linser
    Department NMR-Based Structural Biology, Max-Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany;
  • Nicola Salvi
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;
  • Rodolfo Briones
    Biomolecular Dynamics Group, Max-Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
  • Petra Rovó
    Department NMR-Based Structural Biology, Max-Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany;
  • Bert L. de Groot
    Biomolecular Dynamics Group, Max-Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
  • Gerhard Wagner
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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<jats:title>Significance</jats:title> <jats:p>Sterol regulatory element-binding protein (SREBP) signaling is responsible for transcriptional regulation of cellular lipid homeostasis. Aberrant regulation of the feedback loop that switches on transcription of related genes upon depletion of fatty acids and cholesterol abrogates cellular integrity and is a hallmark of many cancers and other diseases. Regulated intramembrane proteolysis is a conserved mechanism also involved in other signaling processes like Wnt and Notch and defines cellular regulation from homeostasis to proliferation, compartmentalization, and differentiation. An understanding of basic features, however, such as substrate selectivity and specificity, has remained elusive to date. Understanding the proteolysis of the SREBP precursor is an important goal both for understanding and medically intervening in SREBP signaling and related diseases as well as for understanding other regulated intramembrane proteolysis-dependent processes.</jats:p>

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