Effects of sleep modulation during pregnancy in the mother and offspring: Evidences from preclinical research

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  • Gabriel Natan Pires
    Departamento de Psicobiologia Universidade Federal de São Paulo São Paulo Brazil
  • Luciana Benedetto
    Departamento de Fisiología Facultad de Medicina Universidad de la República Montevideo Uruguay
  • Rene Cortese
    Department of Child Health and Child Health Research Institute University of Missouri School of Medicine Columbia MO USA
  • David Gozal
    Department of Child Health and Child Health Research Institute University of Missouri School of Medicine Columbia MO USA
  • Kamalesh K. Gulia
    Division of Sleep Research Biomedical Technology Wing – Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala India
  • Velayudhan Mohan Kumar
    Kerala Chapter (Convenor) National Academy of Medical Sciences New Delhi India
  • Sergio Tufik
    Departamento de Psicobiologia Universidade Federal de São Paulo São Paulo Brazil
  • Monica Levy Andersen
    Departamento de Psicobiologia Universidade Federal de São Paulo São Paulo Brazil

書誌事項

公開日
2020-07-02
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/jsr.13135
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Disturbed sleep during gestation may lead to adverse outcomes for both mother and child. Animal research plays an important role in providing insights into this research field by enabling ethical and methodological requirements that are not possible in humans. Here, we present an overview and discuss the main research findings related to the effects of prenatal sleep deprivation in animal models. Using systematic review approaches, we retrieved 42 articles dealing with some type of sleep alteration. The most frequent research topics in this context were maternal sleep deprivation, maternal behaviour, offspring behaviour, development of sleep–wake cycles in the offspring, hippocampal neurodevelopment, pregnancy viability, renal physiology, hypertension and metabolism. This overview indicates that the number of basic studies in this field is growing, and provides biological plausibility to suggest that sleep disturbances might be detrimental to both mother and offspring by promoting increased risk at the behavioural, hormonal, electrophysiological, metabolic and epigenetic levels. More studies on the effects of maternal sleep deprivation are needed, in light of their major translational perspective.</jats:p>

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