Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

DOI Web Site 1 Citations
  • Mingyue Sun
    School of Fundamental Sciences, China Medical University, Shenyang 110122, China
  • Xiaoting Sun
    School of Fundamental Sciences, China Medical University, Shenyang 110122, China
  • Ziyuan Wang
    The Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, China
  • Shuyu Guo
    The Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, China
  • Guangjiao Yu
    The Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, China
  • Huazhe Yang
    School of Fundamental Sciences, China Medical University, Shenyang 110122, China

Description

<jats:p>Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light to crosslink the gelatin-methacrylic anhydride (MA) precursor was introduced in detail. In addition, the traditional and cutting-edge technologies to characterize the properties of GelMA hydrogels and GelMA prepolymer were also overviewed and compared. Furthermore, the applications of GelMA hydrogels in cell culture and tissue engineering especially in the load-bearing tissue (bone and cartilage) were summarized, followed by concluding remarks.</jats:p>

Journal

  • Polymers

    Polymers 10 (11), 1290-, 2018-11-21

    MDPI AG

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