Problems with Using Polygenic Scores to Select Embryos

Patrick Turley, Michelle N. Meyer, Nancy Wang, David Cesarini, Evelynn Hammonds, Alicia R. Martin, Benjamin M. Neale, Heidi L. Rehm, Louise Wilkins-Haug, Daniel J. Benjamin, Steven Hyman, David Laibson, Peter M. Visscher

doi:10.1056/nejmsr2105065

Problems with Using Polygenic Scores to Select Embryos

DOI Web Site 被引用文献1件

Patrick Turley

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Michelle N. Meyer

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Nancy Wang

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
David Cesarini

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Evelynn Hammonds

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Alicia R. Martin

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Benjamin M. Neale

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Heidi L. Rehm

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Louise Wilkins-Haug

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Daniel J. Benjamin

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Steven Hyman

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
David Laibson

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...
Peter M. Visscher

From the University of Southern California (P.T.) and the University of California, Los Angeles (D.J.B.) — both in Los Angeles; Geisinger Health System, Danville, PA (M.N.M.); the National Bureau of Economic Research (N.W., D.C., D.J.B., D.L.), Harvard University (E.H., S.H., D.L.), and the Broad Institute of Harvard and MIT (A.R.M., B.M.N., H.L.R., S.H.) — all in Cambridge, MA; Massachusetts General Hospital (A.R.M., B.M.N., H.L.R.), Harvard Medical School (A.R.M., B.M.N., H.L.R., L.W.-H.), and Brigham...