Long-term analgesic effect of a single dose of anti-NGF antibody on pain during motion without notable suppression of joint edema and lesion in a rat model of osteoarthritis
書誌事項
- 公開日
- 2015-06
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- http://www.elsevier.com/open-access/userlicense/1.0/
- DOI
-
- 10.1016/j.joca.2015.02.002
- 公開者
- Elsevier BV
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説明
Osteoarthritis (OA) patients experience exaggerated pain during movements such as walking. Anti-nerve growth factor (NGF) antibodies have recently shown analgesic effects in OA patients. We examined the effect of a single dose of anti-NGF antibody on pain during motion, joint edema and lesion in a rat model of OA to determine whether the analgesic effect demonstrated in clinical studies can be translated to a preclinical model.Sodium monoiodoacetate (MIA)-induced arthritic rats that develop a right-left gait imbalance when walking as an index of pain during motion. This imbalance was assessed using a gait analysis system called "CatWalk". Edema size and lesion score in the relevant knee joint were also measured. The effect of a single intravenous injection of an anti-NGF monoclonal antibody AS2886401-00 on these parameters was assessed.AS2886401-00 administered at 0.3 or 1 mg/kg on Day 3 post-MIA injection resulted in a statistically significant improvement in gait imbalance even on Day 35. When gait measurement was set on Week 3 post-MIA administration, administration of the antibody at a timing close to the gait measurement, i.e., 1 or 24 h prior to the measurement, was less effective. AS2886401-00 did not suppress either edema or lesion.A single dose of anti-NGF antibody exerts a long-lasting analgesic effect on pain during motion in a rat model of OA. This finding could be associated with the analgesic efficacies that anti-NGF antibodies have exhibited in clinical studies. It appears unlikely that analgesia is secondary to inhibition of joint edema and lesion.
収録刊行物
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- Osteoarthritis and Cartilage
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Osteoarthritis and Cartilage 23 (6), 925-932, 2015-06
Elsevier BV
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キーワード
- Male
- Joint edema and lesion
- Biomedical Engineering
- Drug Evaluation, Preclinical
- Pain
- Drug Administration Schedule
- Rats, Sprague-Dawley
- Motion
- Rheumatology
- Nerve Growth Factor
- Osteoarthritis
- Animals
- Edema
- Orthopedics and Sports Medicine
- Pain Measurement
- Pain during motion
- Antibodies, Monoclonal
- Analgesics, Non-Narcotic
- Arthritis, Experimental
- Treatment Outcome
- Antibody of nerve growth factor
- Sodium monoiodoacetate
- Joint Diseases