Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury
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- Wei-kun Zhao
- Department of Health Care Ward, First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541001, China
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- Yao Zhou
- Department of Pathophysiology, Xuzhou Medical University, Xuzhou, Jiangsu province 221009, China
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- Tong-tong Xu
- Department of Health Care Ward, First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541001, China
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- Qi Wu
- Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu province 221009, China
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- HAOBO LI
- editor
説明
<jats:p>Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI.</jats:p>
収録刊行物
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- Oxidative Medicine and Cellular Longevity
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Oxidative Medicine and Cellular Longevity 2021 1-12, 2021-10-23
Hindawi Limited
