Cardiac computed tomography in cardio-oncology: an update on recent clinical applications

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  • Stefania Rosmini
    Cardiology Department, Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK
  • Ankita Aggarwal
    Department of Internal Medicine, Wayne State University, Providence Hospital, Rochester, MI, USA
  • Daniel H Chen
    Cardiology Department, Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK
  • John Conibear
    Oncology Department, Barts Cancer Centre, St Bartholomew’s Hospital London, UK
  • Ceri L Davies
    Cardiology Department, Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK
  • Amit Kumar Dey
    National Heart, Lung and Blood Institute, Bethesda, USA
  • Paula Edwards
    Rollins School of Public Health, Emory University, Atlanta, GA, USA
  • Avirup Guha
    Harrington Heart and Vascular Institute, Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
  • Arjun K Ghosh
    Cardiology Department, Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK

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<jats:title>Abstract</jats:title> <jats:p>Chemotherapy and radiotherapy have drastically improved cancer survival, but they can result in significant short- and long-term cardiovascular complications, most commonly heart failure from chemotherapy, whilst radiotherapy increases the risk of premature coronary artery disease (CAD), valve, and pericardial diseases. Cardiac computed tomography (CT) with calcium scoring has a role in screening asymptomatic patients for premature CAD, cardiac CT angiography (CTCA) allows the identification of significant CAD, also in the acute settings where concerns exist towards invasive angiography. CTCA integrates the diagnostic work-up and guides surgical/percutaneous management of valvular heart diseases and allows the assessment of pericardial conditions, including detection of effusion and pericardial calcification. It is a widely available and fast imaging modality that allows a one-step evaluation of CAD, myocardial, valvular, and pericardial disease. This review aims to provide an update on its current use and accompanying evidence-base for cardiac CT in the management of cardio-oncology patients.</jats:p>

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