The herpes simplex virus ICP27 protein: a multifunctional post-transcriptional regulator of gene expression
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- R.W.P. Smith
- Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, U.K.
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- P. Malik
- Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, U.K.
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- J.B. Clements
- Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, Scotland, U.K.
書誌事項
- 公開日
- 2005-06-01
- DOI
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- 10.1042/bst0330499
- 公開者
- Portland Press Ltd.
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説明
<jats:p>The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. These activities are discussed.</jats:p>
収録刊行物
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- Biochemical Society Transactions
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Biochemical Society Transactions 33 (3), 499-501, 2005-06-01
Portland Press Ltd.