Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection

DOI Web Site 被引用文献2件
  • Paul K. Drain
    Department of Global Health, University of Washington, Seattle, Washington, USA
  • Kristina L. Bajema
    Department of Medicine, University of Washington, Seattle, Washington, USA
  • David Dowdy
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
  • Keertan Dheda
    University of Cape Town, Cape Town, South Africa
  • Kogieleum Naidoo
    Centre for the AIDS Programme of Research in Africa, Durban, South Africa
  • Samuel G. Schumacher
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
  • Shuyi Ma
    Department of Global Health, University of Washington, Seattle, Washington, USA
  • Erin Meermeier
    Oregon Health and Science University, Portland, Oregon, USA
  • David M. Lewinsohn
    Oregon Health and Science University, Portland, Oregon, USA
  • David R. Sherman
    Department of Global Health, University of Washington, Seattle, Washington, USA

書誌事項

公開日
2018-10
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/cmr.00021-18
公開者
American Society for Microbiology

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説明

<jats:title>SUMMARY</jats:title><jats:p>Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a limited understanding of its clinical pathogenic spectrum of infection and disease. Historically, scientific research, diagnostic testing, and drug treatment have focused on addressing one of two disease states: latent TB infection or active TB disease. Recent research has clearly demonstrated that human TB infection, from latent infection to active disease, exists within a continuous spectrum of metabolic bacterial activity and antagonistic immunological responses. This revised understanding leads us to propose two additional clinical states: incipient and subclinical TB. The recognition of incipient and subclinical TB, which helps divide latent and active TB along the clinical disease spectrum, provides opportunities for the development of diagnostic and therapeutic interventions to prevent progression to active TB disease and transmission of TB bacilli. In this report, we review the current understanding of the pathogenesis, immunology, clinical epidemiology, diagnosis, treatment, and prevention of both incipient and subclinical TB, two emerging clinical states of an ancient bacterium.</jats:p>

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