Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

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  • Shuling Song
    Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China
  • Tamara Tchkonia
    Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester MN 55905 USA
  • Jing Jiang
    School of Pharmacy Binzhou Medical University Yantai Shandong 264003 China
  • James L. Kirkland
    Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester MN 55905 USA
  • Yu Sun
    Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China

Abstract

<jats:title>Abstract</jats:title><jats:p>Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age‐related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age‐related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age‐related disorders in the current era of precision medicine.</jats:p>

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