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- M. Monk
- MRC Mammalian Development Unit 1 , 4 Stephenson Way, London NW1 2HE, UK
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- R. L. P. Adams
- Department of Biochemistry 2 , University of Glasgow, Glasgow G12 8QQ, UK
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- A. Rinaldi
- Department of Biochemistry 2 , University of Glasgow, Glasgow G12 8QQ, UK
説明
<jats:title>ABSTRACT</jats:title> <jats:p>During early mouse development, there are large-scale changes in DNA methylation. These changes may be due to the availability or stability of the enzyme, DNA methyltransferase (methylase), which is responsible for maintenance of DNA methylation. A microassay for methylase activity in preimplantation embryos shows that the level of maternally inherited enzyme is extremely high in the egg and that this activity is stable for the first three cleavage divisions. However, from the 8-cell to the blastocyst stage, there is a marked and absolute decrease in enzyme activity.</jats:p>
収録刊行物
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- Development
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Development 112 (1), 189-192, 1991-05-01
The Company of Biologists