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- Christopher J. Derrick
- Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
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- Emily S. Noël
- Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
書誌事項
- 公開日
- 2021-03-01
- 権利情報
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- http://www.biologists.com/user-licence-1-1
- DOI
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- 10.1242/dev.191320
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p>The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition of specific ECM components creates matrix diversity, the cardiac ECM is also dynamic, with modification and degradation playing important roles in ECM maturation and function. In this Review, we discuss the spatiotemporal changes in ECM composition during cardiac development that support distinct aspects of heart morphogenesis. We highlight conserved requirements for specific ECM components in human cardiac development, and discuss emerging evidence of a central role for the ECM in promoting heart regeneration.</jats:p>
収録刊行物
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- Development
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Development 148 (5), 2021-03-01
The Company of Biologists
