Plant ESCRT protein ALIX coordinates with retromer complex in regulating receptor-mediated sorting of soluble vacuolar proteins

DOI Web Site 参考文献60件
  • Shuai Hu
    State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, 311300 Hangzhou, China
  • Baiying Li
    Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
  • Fan Wu
    State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, 311300 Hangzhou, China
  • Dongmei Zhu
    State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, 311300 Hangzhou, China
  • Jan Zouhar
    Central European Institute of Technology, Mendel University in Brno, CZ-61300 Brno, Czech Republic
  • Caiji Gao
    Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, 510631, China
  • Tomoo Shimada
    Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
  • Enrique Rojo
    Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Cantoblanco, E-28049 Madrid, Spain
  • Ikuko Hara-Nishimura
    Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan
  • Liwen Jiang
    Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
  • Jinbo Shen
    State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, 311300 Hangzhou, China

説明

<jats:title>Significance</jats:title><jats:p>The endosomal sorting complex required for transport (ESCRT) machinery in multicellular organisms plays canonical functions in multivesicular body (MVB) biogenesis and membrane protein sorting. Nonetheless, its critical role in the sorting of soluble vacuolar proteins and its interplay with endosomal recycling machinery have yet to be reported. In this study, we demonstrate that<jats:italic>Arabidopsis</jats:italic>ESCRT-associated ALIXinteracts with the retromer core subunitsto regulate their recruitment onto endosome membrane for recycling of vacuolar sorting receptors (VSRs) for efficient sorting of soluble vacuolar proteins. This work provides molecular insights into the unique properties of ALIX in regulating vacuolar transport of soluble proteins, thus shedding new light on the crosstalk and coordination between the vacuolar trafficking and endosomal recycling pathways in plants.</jats:p>

収録刊行物

参考文献 (60)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ