Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study
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- Kunihiro Sonoda
- Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya 463-8521, Japan
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- Yuka Kono
- Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya 463-8521, Japan
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- Kazuya Kitamori
- Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya 463-8521, Japan
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- Kazuo Ohtake
- Division of Physiology, School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0248, Japan
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- Sachiko Shiba
- Division of Physiology, School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0248, Japan
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- Keizo Kasono
- Division of Physiology, School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0248, Japan
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- Jun Kobayashi
- Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0248, Japan
書誌事項
- 公開日
- 2022-03-08
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/ijms23062931
- 公開者
- MDPI AG
説明
<jats:p>Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 23 (6), 2931-, 2022-03-08
MDPI AG
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キーワード
- Liver Cirrhosis
- Captopril
- nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; nitric oxide; nitrite; nitrate; angiotensin II; angiotensin II type 1 receptor; captopril; nicotinamide adenine dinucleotide phosphate oxidase; endothelial dysfunction
- Diet, High-Fat
- Article
- Rats
- Disease Models, Animal
- Cholesterol
- Liver
- Non-alcoholic Fatty Liver Disease
- Rats, Inbred SHR
- Animals
- Nitrites
詳細情報 詳細情報について
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- CRID
- 1360298337100729088
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- ISSN
- 14220067
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- PubMed
- 35328352
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE