Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

DOI Web Site 2 Citations
  • Guangbo Liu
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
  • Fen Pei
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
  • Fengqing Yang
    Department of Obstetrics and Gynecology, Dong’e No. 4 People’s Hospital, Liaocheng 252200, China
  • Lingxiao Li
    Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Amit Amin
    Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
  • Songnian Liu
    Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
  • J. Buchan
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
  • William Cho
    Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China

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<jats:p>Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading cause of cancer-related death worldwide. The poor prognosis and resistance to both radiation and chemotherapy warrant further investigation into the molecular mechanisms of NSCLC and the development of new, more efficacious therapeutics. The processes of autophagy and apoptosis, which induce degradation of proteins and organelles or cell death upon cellular stress, are crucial in the pathophysiology of NSCLC. The close interplay between autophagy and apoptosis through shared signaling pathways complicates our understanding of how NSCLC pathophysiology is regulated. The apoptotic effect of autophagy is controversial as both inhibitory and stimulatory effects have been reported in NSCLC. In addition, crosstalk of proteins regulating both autophagy and apoptosis exists. Here, we review the recent advances of the relationship between autophagy and apoptosis in NSCLC, aiming to provide few insights into the discovery of novel pathogenic factors and the development of new cancer therapeutics.</jats:p>

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