The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update

  • Marcus Maurer
    Institute of Allergology Charité—Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
  • Markus Magerl
    Institute of Allergology Charité—Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
  • Stephen Betschel
    University of Toronto Toronto ON Canada
  • Werner Aberer
    Department of Dermatology Medical University of Graz Graz Austria
  • Ignacio J. Ansotegui
    Department of Allergy & Immunology Hospital Quironsalud Bizkaia Bilbao Spain
  • Emel Aygören‐Pürsün
    Center for Children and Adolescents University Hospital Frankfurt Frankfurt Germany
  • Aleena Banerji
    Division of Rheumatology, Allergy and Immunology Massachusetts General Hospital Boston Massachusetts USA
  • Noémi‐Anna Bara
    Romanian Hereditary Angioedema Expertise Centre Mediquest Clinical Research Center Sangeorgiu de Mures Romania
  • Isabelle Boccon‐Gibod
    National Reference Center for Angioedema (CREAK) Angioedema Center of Reference and Excellence (ACARE) Grenoble Alpes University Hospital Grenoble France
  • Konrad Bork
    Department of Dermatology University Medical Center Johannes Gutenberg University Mainz Germany
  • Laurence Bouillet
    National Reference Center for Angioedema (CREAK) Angioedema Center of Reference and Excellence (ACARE) Grenoble Alpes University Hospital Grenoble France
  • Henrik Balle Boysen
    HAE International (HAEi) Skanderborg Denmark
  • Nicholas Brodszki
    Department of Pediatric Immunology Childrens Hospital Skåne University Hospital Lund Sweden
  • Paula J. Busse
    Icahn School of Medicine at Mount Sinai New York NY USA
  • Anette Bygum
    Clinical Institute University of Southern Denmark Odense Denmark
  • Teresa Caballero
    Allergy Department Hospital Universitario La Paz IdiPaz, CIBERER U754 Madrid Spain
  • Mauro Cancian
    Department of Systems Medicine University Hospital of Padua Padua Italy
  • Anthony Castaldo
    HAE International (HAEi) Skanderborg Denmark
  • Danny M. Cohn
    Department of Vascular Medicine Amsterdam UMC/University of Amsterdam Amsterdam The Netherlands
  • Dorottya Csuka
    Department of Internal Medicine and Haematology Hungarian Angioedema Center of Reference and Excellence Semmelweis University Budapest Hungary
  • Henriette Farkas
    Department of Internal Medicine and Haematology Hungarian Angioedema Center of Reference and Excellence Semmelweis University Budapest Hungary
  • Mark Gompels
    Clinical Immunology North Bristol NHS Trust Bristol UK
  • Richard Gower
    Marycliff Clinical Research Principle Research Solutions Spokane Washington USA
  • Anete S. Grumach
    Clinical Immunology Centro Universitario FMABC Sao Paulo Brazil
  • Guillermo Guidos‐Fogelbach
    Instituto Politécnico Nacional SEPI‐ENMH Mexico City Mexico
  • Michihiro Hide
    Department of Dermatology Hiroshima Citizens Hospital Hiroshima Japan
  • Hye‐Ryun Kang
    Department of Internal Medicine Seoul National University College of Medicine Seoul Korea
  • Allen Phillip Kaplan
    Division of Pulmonary, Critical Care, Allergy and Immunology Medical university of South Carolina Charleston South Carolina USA
  • Constance Katelaris
    Department of Medicine Campbelltown Hospital and Western Sydney University Sydney NSW Australia
  • Sorena Kiani‐Alikhan
    Department of Immunology Barts Health NHS Trust London UK
  • Wei‐Te Lei
    Division of Allergy, Immunology, and Rheumatology Department of Pediatrics Mackay Memorial Hospital Hsinchu Taiwan
  • Richard Lockey
    Division of Allergy and Immunology Department of Internal Medicine Morsani College of Medicine University of South Florida Tampa Florida USA
  • Hilary Longhurst
    Department of Immunology Auckland District Health Board and Department of Medicine University of Auckland Auckland New Zealand
  • William R. Lumry
    Internal Medicine Allergy Division University of Texas Health Science Center Dallas Texas USA
  • Andrew MacGinnitie
    Division of Immunology Department of Pediatrics Boston Children's Hospital Harvard Medical School Boston Massachusetts USA
  • Alejandro Malbran
    Unidad de Alergia, Asma e Inmunología Clínica Buenos Aires Argentina
  • Inmaculada Martinez Saguer
    Pediatrics Haemophilia Centre Rhine Main (HZRM) Moerfelden‐Walldorf Germany
  • Juan José Matta
    H. Especialidades C.M.N.SXXI, I.M.S.S. México City Mexico
  • Alexander Nast
    Department of Dermatology, Venereology and Allergology Division of Evidence‐Based Medicine Charité ‐ Universitätsmedizin Berlin corporate member of Free University of Berlin Humboldt University of Berlin, and Berlin Institute of Health Berlin Germany
  • Dinh Nguyen
    Respiratory, Allergy and Clinical Immunology Unit Internal Medicine Department Vinmec Healthcare System College of Health Sciences VinUniversity Hanoi Vietnam
  • Sandra A. Nieto‐Martinez
    Genetic Unit of Nutrition National Institute of Pediatrics Mexico City Mexico
  • Ruby Pawankar
    Department of Pediatrics Nippon Medical School Tokyo Japan
  • Jonathan Peter
    Division of Allergy and Clinical Immunology University of Cape Town Cape Town South Africa
  • Grzegorz Porebski
    Department of Clinical and Environmental Allergology Jagiellonian University Medical College Krakow Poland
  • Nieves Prior
    Allergy Hospital Universitario Severo Ochoa Madrid Spain
  • Avner Reshef
    Angioderma Center Barzilai University Medical Center Ashkelon Israel
  • Marc Riedl
    Division of Rheumatology, Allergy and Immunology University of California San Diego La Jolla California USA
  • Bruce Ritchie
    Departments of Medicine and Medical Oncology University of Alberta Edmonton AB Canada
  • Farrukh Rafique Sheikh
    Section of Adult Allergy & Immunology Department of Medicine King Faisal Specialist Hospital & Research Centre Riyadh Saudi Arabia
  • William B. Smith
    Clinical Immunology and Allergy Royal Adelaide Hospital Adelaide SA Australia
  • Peter J. Spaeth
    Institute of Pharmacology University of Bern Bern Switzerland
  • Marcin Stobiecki
    Department of Clinical and Environmental Allergology Jagiellonian University Medical College Krakow Poland
  • Elias Toubi
    Division of Allergy and Clinical Immunology Bnai Zion Medical Center Affiliated with Rappaport Faculty of Medicine Technion‐Israel Institute of Technology Haifa Israel
  • Lilian Agnes Varga
    Department of Internal Medicine and Haematology Hungarian Angioedema Center of Reference and Excellence Semmelweis University Budapest Hungary
  • Karsten Weller
    Institute of Allergology Charité—Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
  • Andrea Zanichelli
    Department of Internal Medicine ASST Fatebenefratelli Sacco Ospedale Luigi Sacco‐University of Milan Milan Italy
  • Yuxiang Zhi
    Department of Allergy and Clinical Immunology Bejing Union Medical College Hospital & Chinese Academy of Medical Sciences Bejing China
  • Bruce Zuraw
    University of California, San Diego San Diego California USA
  • Timothy Craig
    Departments of Medicine and Pediatrics Penn State University Hershey Pennsylvania USA

抄録

<jats:title>Abstract</jats:title><jats:p>Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on‐demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast‐feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients.</jats:p>

収録刊行物

  • Allergy

    Allergy 77 (7), 1961-1990, 2022-02-03

    Wiley

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