Adjunctive kampo therapy for incomplete Kawasaki disease mimic associated with reaction at the bacillus Calmette–Guérin inoculation site

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Abstract

<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>We report two cases of incomplete Kawasaki disease (IKD) mimic associated with bacillus Calmette–Guérin (BCG) inoculation site reaction that were treated with Japanese traditional herbal (kampo) medicine, eppikajutsuto (EJT), as an adjunct to high‐dose oral acetylsalicylic acid in the early disease stage.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Physical findings, such as peripheral edematous erythema of the extremities and BCG site change in febrile infants, were strongly suggestive of IKD. Additionally, they were suitable for treatment with EJT. After EJT treatment, the physical findings of inflammation disappeared. C‐reactive protein decreased to the normal range. Repeat echocardiography showed no coronary arterial lesions.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>EJT (kampo medicine) has a potential adjunctive role in the acute‐phase management of IKD mimic. Further study on the adjunct efficacy of EJT is needed in patients with IKD and BCG site reactivation.</jats:p></jats:sec>

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