Herpesvirus infections, antiviral treatment, and the risk of dementia—a registry‐based cohort study in Sweden
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- Karin Lopatko Lindman
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Eva‐Stina Hemmingsson
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Bodil Weidung
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Jon Brännström
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Maria Josefsson
- Centre for Demographic and Ageing Research Umeå University Umeå Sweden
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- Jan Olsson
- Department of Clinical Microbiology, Virology Umeå University Umeå Sweden
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- Fredrik Elgh
- Department of Clinical Microbiology, Virology Umeå University Umeå Sweden
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- Peter Nordström
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Hugo Lövheim
- Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
Description
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against dementia development in herpes‐infected individuals.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The study enrolled 265,172 subjects aged ≥ 50 years, with diagnoses of VZV or HSV, or prescribed antiviral drugs between 31 December 2005 and 31 December 2017. Controls were matched in a 1:1 ratio by sex and birth year.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Antiviral treatment was associated with decreased risk of dementia (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.86 to 0.92), while herpes infection without antiviral drugs increased the risk of dementia (adjusted HR 1.50, 95% CI 1.29 to 1.74).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Antiviral treatment was associated with a reduced long‐term risk of dementia among individuals with overt signs of herpes infection. This is consistent with earlier findings indicating that herpesviruses are involved in the pathogenesis of AD.</jats:p></jats:sec>
Journal
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- Alzheimer's & Dementia: Translational Research & Clinical Interventions
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Alzheimer's & Dementia: Translational Research & Clinical Interventions 7 (1), 2021-01
Wiley
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Details 詳細情報について
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- CRID
- 1360298342483021952
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- ISSN
- 23528737
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- Data Source
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- Crossref