Memory CD4 T Cells Enhance Primary CD8 T-Cell Responses

DOI Web Site 被引用文献1件
  • Connie M. Krawczyk
    Department of Pathobiology, School of Veterinary Medicine
  • Hao Shen
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
  • Edward J. Pearce
    Department of Pathobiology, School of Veterinary Medicine

説明

<jats:title>ABSTRACT</jats:title> <jats:p>CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisiting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.</jats:p>

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