Yield of Screening for COVID-19 in Asymptomatic Patients Before Elective or Emergency Surgery Using Chest CT and RT-PCR (SCOUT)

  • Carl A. J. Puylaert
    Department of Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Jochem C. G. Scheijmans
    Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Alexander B. J. Borgstein
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Caroline S. Andeweg
    Department of Surgery, St Jansdal Hospital, Harderwijk, the Netherlands
  • Annemarieke Bartels-Rutten
    Department of Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • Geerard L. Beets
    Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • Mark I. van Berge Henegouwen
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Sicco J. Braak
    Department of Radiology, Hospital Group Twente, Almelo, the Netherlands
  • Roy Couvreur
    Department of Surgery, Haaglanden Medical Center, Den Haag, the Netherlands
  • Freek Daams
    Department of Surgery, Cancer Center Amsterdam UMC, VU University Amsterdam, Amsterdam, the Netherlands
  • Hendrik W. van Es
    Department of Radiology, Sint Antonius Hospital, Nieuwegein, the Netherlands
  • Lotte C. Franken
    Department of Surgery, Flevo Hospital, Almere, the Netherlands
  • Brechtje A. Grotenhuis
    Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • Eduard R. Hendriks
    Department of Surgery, Tergooi Hospitals, Hilversum, the Netherlands
  • Ignace H. J. T. de Hingh
    Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands
  • Fieke Hoeijmakers
    Department of Surgery, Dijklander Hospital, Hoorn, the Netherlands
  • Joris T. ten Holder
    Department of Pulmonary Medicine, Haaglanden Medical Center, Den Haag, the Netherlands
  • Peter M. Huisman
    Department of Radiology, Tergooi Hospitals, Hilversum, the Netherlands
  • Geert Kazemier
    Department of Surgery, Cancer Center Amsterdam UMC, VU University Amsterdam, Amsterdam, the Netherlands
  • Floortje van Kesteren
    Department of Radiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Jurre van Kesteren
    Department of Surgery, Dijklander Hospital, Hoorn, the Netherlands
  • Kammy Keywani
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Sara Z. Kuiper
    Department of Surgery, Maastricht UMC+, Maastricht, the Netherlands
  • Maurits D. J. Lange
    Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • Mark E. Lobatto
    Department of Radiology, Spaarne Gasthuis, Haarlem and Hoofddorp, the Netherlands
  • Arthur W. F. du Mée
    Department of Radiology, Amphia Hospital, Breda, the Netherlands
  • Martijn Poeze
    Department of Surgery, Maastricht UMC+, Maastricht, the Netherlands
  • Elise M. van Praag
    Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Jorit van Rossen
    Department of Radiology, Hospital Group Twente, Almelo, the Netherlands
  • Hjalmar C. van Santvoort
    Department of Surgery, Sint Antonius Hospital, Nieuwegein, the Netherlands
  • Wouter J. A. Sedee
    Department of Emergency Medicine, St Jansdal Hospital, Harderwijk, the Netherlands
  • Leonard W. F. Seelen
    Department of Surgery, Sint Antonius Hospital, Nieuwegein, the Netherlands
  • Sarah Sharabiany
    Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Nico L. Sosef
    Department of Surgery, Spaarne Gasthuis, Haarlem and Hoofddorp, the Netherlands
  • Marian J. R. Quanjel
    Department of Pulmonary Medicine, Sint Antonius Hospital, Nieuwegein, the Netherlands
  • Jeroen Veltman
    Department of Radiology, Hospital Group Twente, Almelo, the Netherlands
  • Tim Verhagen
    Department of Surgery, Hospital Group Twente, Almelo, the Netherlands
  • Vincent C. J. van de Vlasakker
    Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands
  • Pepijn D. Weeder
    Department of Surgery, Spaarne Gasthuis, Haarlem and Hoofddorp, the Netherlands
  • Jochem R. van Werven
    Department of Radiology, Amphia Hospital, Breda, the Netherlands
  • Nina J. Wesdorp
    Department of Surgery, Cancer Center Amsterdam UMC, VU University Amsterdam, Amsterdam, the Netherlands
  • Susan van Dieren
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Alvin X. Han
    Laboratory of Applied Evolutionary Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Colin A. Russell
    Laboratory of Applied Evolutionary Biology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Menno D. de Jong
    Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Patrick M. M. Bossuyt
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Jet M. E. Quarles van Ufford
    Department of Radiology, Haaglanden Medical Center, Den Haag, the Netherlands
  • Mathias W. Prokop
    Department of Radiology, Radboud UMC, Nijmegen, the Netherlands
  • Suzanne S. Gisbertz
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Jan M. Prins
    Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Marc G. Besselink
    Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Marja A. Boermeester
    Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
  • Hester A. Gietema
    Department of Radiology, Maastricht UMC+, Maastricht, the Netherlands.
  • Jaap Stoker
    Department of Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

書誌事項

タイトル別名
  • Multicenter Study

抄録

<jats:sec> <jats:title>Objective:</jats:title> <jats:p>To determine the yield of preoperative screening for COVID-19 with chest CT and RT-PCR in patients without COVID-19 symptoms.</jats:p> </jats:sec> <jats:sec> <jats:title>Summary of Background Data:</jats:title> <jats:p>Many centers are currently screening surgical patients for COVID-19 using either chest CT, RT-PCR or both, due to the risk for worsened surgical outcomes and nosocomial spread. The optimal design and yield of such a strategy are currently unknown.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>This multicenter study included consecutive adult patients without COVID-19 symptoms who underwent preoperative screening using chest CT and RT-PCR before elective or emergency surgery under general anesthesia.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>A total of 2093 patients without COVID-19 symptoms were included in 14 participating centers; 1224 were screened by CT and RT-PCR and 869 by chest CT only. The positive yield of screening using a combination of chest CT and RT-PCR was 1.5% [95% confidence interval (CI): 0.8–2.1]. Individual yields were 0.7% (95% CI: 0.2–1.1) for chest CT and 1.1% (95% CI: 0.6–1.7) for RT-PCR; the incremental yield of chest CT was 0.4%. In relation to COVID-19 community prevalence, up to ∼6% positive RT-PCR was found for a daily hospital admission rate >1.5 per 100,000 inhabitants, and around 1.0% for lower prevalence.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>One in every 100 patients without COVID-19 symptoms tested positive for SARS-CoV-2 with RT-PCR; this yield increased in conjunction with community prevalence. The added value of chest CT was limited. Preoperative screening allowed us to take adequate precautions for SARS-CoV-2 positive patients in a surgical population, whereas negative patients needed only routine procedures.</jats:p> </jats:sec>

収録刊行物

  • Annals of Surgery

    Annals of Surgery 272 (6), 919-924, 2020-07-14

    Ovid Technologies (Wolters Kluwer Health)

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