Phase-tuned neuronal firing encodes human contextual representations for navigational goals
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- Andrew J Watrous
- Department of Biomedical Engineering, Columbia University, New York, United States
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- Jonathan Miller
- Department of Biomedical Engineering, Columbia University, New York, United States
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- Salman E Qasim
- Department of Biomedical Engineering, Columbia University, New York, United States
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- Itzhak Fried
- Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States
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- Joshua Jacobs
- Department of Biomedical Engineering, Columbia University, New York, United States
説明
<jats:p>We previously demonstrated that the phase of oscillations modulates neural activity representing categorical information using human intracranial recordings and high-frequency activity from local field potentials (Watrous et al., 2015b). We extend these findings here using human single-neuron recordings during a virtual navigation task. We identify neurons in the medial temporal lobe with firing-rate modulations for specific navigational goals, as well as for navigational planning and goal arrival. Going beyond this work, using a novel oscillation detection algorithm, we identify phase-locked neural firing that encodes information about a person’s prospective navigational goal in the absence of firing rate changes. These results provide evidence for navigational planning and contextual accounts of human MTL function at the single-neuron level. More generally, our findings identify phase-coded neuronal firing as a component of the human neural code.</jats:p>
収録刊行物
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- eLife
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eLife 7 2018-06-22
eLife Sciences Publications, Ltd
