-
- Christopher Zhe Wei Lee
- Singapore Immunology Network, 8A Biomedical Grove 1 , Singapore 138648 , Singapore
-
- Florent Ginhoux
- Singapore Immunology Network, 8A Biomedical Grove 1 , Singapore 138648 , Singapore
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Although best known for their phagocytic and immunological functions, macrophages have increasingly been recognised as key players in the development, homeostasis and regeneration of their host tissues. Early during development, macrophages infiltrate and colonise all tissues within the body, developing symbiotically with their host tissues and acquiring unique functional adaptations based on the tissue microenvironment. These embryonic resident tissue macrophages (RTMs) are ontogenically distinct from the later adult bone marrow-derived monocytes, and in some tissues are self-maintained independently of general circulation at a steady state. In this article, we briefly discuss the ontogeny, maintenance and unique tissue adaptions of RTMs focusing on microglia, Kupffer cells, Langerhans cells, intestinal macrophages, cardiac macrophages and tumour-associated macrophages, and highlight their role in development, homeostasis and dysfunction.</jats:p>
収録刊行物
-
- Development
-
Development 149 (8), 200270-, 2022-04-15
The Company of Biologists