Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia
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- Yoshihiro Hatta
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
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- Yasuaki Yamada
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
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- Masao Tomonaga
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
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- Isao Miyoshi
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
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- Jonathan W. Said
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
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- H. Phillip Koeffler
- From the Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of Laboratoy Medicine and the Department of Hematology, Nagasaki University School of Medicine, Nagasaki, Japan; the Department of Medicine, Kochi Medical School, Kochi, Japan; and the Department of Pathology, Center for the Health Science, UCLA School of Medicine, Los Angeles, CA.
書誌事項
- 公開日
- 1999-01-15
- DOI
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- 10.1182/blood.v93.2.613.402k13_613_616
- 10.1182/blood.v93.2.613
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:p>Previously, we have found that the loss of heterozygosity (LOH) was frequently observed on chromosome 6q in acute/lymphoma-type adult T-cell leukemia (ATL), suggesting a putative tumor-suppressor gene for ATL may be present on chromosome 6q. To further define a region containing this gene, we performed fine-scale deletional mapping of chromosome 6q in 22 acute/lymphomatous ATL samples using 24 highly informative microsatellite markers. LOH was found in 9 samples (40.9%) at 1 or more of the loci examined. Of the 9 samples, 8 shared the same smallest commonly deleted region flanked by D6S1652 and D6S1644 (6q15-21). The genetic distance between these two loci is approximately 4 cM. These results suggest that a putative tumor-suppressor gene on chromosome 6q15-21 probably plays a very important role in the evolution of acute/lymphomatous ATL. Our map provides key information toward cloning the gene.</jats:p>
収録刊行物
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- Blood
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Blood 93 (2), 613-616, 1999-01-15
American Society of Hematology