Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes
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- Joseph Wybran
- Departments of Immunology and Rheumatology, Saint-Pierre Hospital, Université Libre de Bruxelles , 1000 Brussels, Belgium
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- Thierry Appelboom
- Departments of Immunology and Rheumatology, Saint-Pierre Hospital, Université Libre de Bruxelles , 1000 Brussels, Belgium
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- Jean-Pierre Famaey
- Departments of Immunology and Rheumatology, Saint-Pierre Hospital, Université Libre de Bruxelles , 1000 Brussels, Belgium
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- André Govaerts
- Departments of Immunology and Rheumatology, Saint-Pierre Hospital, Université Libre de Bruxelles , 1000 Brussels, Belgium
説明
<jats:title>Abstract</jats:title> <jats:p>This study reports the in vitro influence of morphine, dextromoramide, levomoramide, and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests. Morphine and dextromoramide inhibited the percentage of active T rosettes. This effect was completely reversed in the presence of naloxone, their specific antagonist. The specificity was further demonstrated by the absence of the effect of levomoramide, the inactive enantiomere, upon the rosette system. Methionine-enkephalin increased the percentage of active T rosettes. This effect was specifically inhibited by naloxone. These observations suggest that normal human blood T lymphocytes bear surface receptor-like structures for morphine, dextromoramide, and methionine-enkephalin. Such findings may provide a link between the central nervous system and the immune system.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 123 (3), 1068-1070, 1979-09-01
The American Association of Immunologists