Ferroptosis in cancer and cancer immunotherapy

DOI Web Site Web Site 1 Citations
  • Lei Zhao
    Epartment of urology surgery Zhejiang hospital Zhejiang University School of Medicine Hangzhou China
  • Xiaoxue Zhou
    School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University Hangzhou Zhejiang 310058 China
  • Feng Xie
    Institutes of Biology and Medical Science Soochow University Suzhou 215123 P. R. China
  • Lei Zhang
    Department of Orthopaedic Surgery the Third Affiliated Hospital of Wenzhou Medical University Rui'an Jiangsu 325000 P. R. China
  • Haiyan Yan
    School of Medicine Zhejiang University City College Hangzhou Zhejiang 310015 China
  • Jun Huang
    School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University Hangzhou Zhejiang 310058 China
  • Chong Zhang
    School of Medicine Zhejiang University City College Hangzhou Zhejiang 310015 China
  • Fangfang Zhou
    Institutes of Biology and Medical Science Soochow University Suzhou 215123 P. R. China
  • Jun Chen
    Epartment of urology surgery Zhejiang hospital Zhejiang University School of Medicine Hangzhou China
  • Long Zhang
    School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University Hangzhou Zhejiang 310058 China

Description

<jats:title>Abstract</jats:title><jats:p>The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.</jats:p>

Journal

Citations (1)*help

See more

Report a problem

Back to top