Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjögren’s syndrome

DOI PDF 被引用文献3件
  • H I Kang
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • H M Fei
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • I Saito
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • S Sawada
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • S L Chen
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • D Yi
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • E Chan
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • C Peebles
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • T L Bugawan
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037
  • H A Erlich
    Department of Immunology and Rheumatology, Scripps Research Institute , La Jolla, CA 92037

書誌事項

公開日
1993-04
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.150.8.3615
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>To better define the genetic factors that predispose to primary Sjögren’s syndrome (SS), we have used polymerase chain reaction in combination with oligonucleotide probe hybridization and DNA sequencing to analyze HLA-DRB1, -DQA1, -DQB1, and -DPB1 alleles in Caucasoid (California), Japanese (Tokyo), and Chinese (Shanghai and Beijing) SS patients. In comparison to local controls in each region, we found: 1) increased frequency of the predicted haplotype HLA-DRB1*0301-DRB3*0101-DQA1*0501-DQB1*0201 in Caucasoid patients (p &lt; 0.001); 2) increased frequency of the predicted haplotype HLA-DRB1*0405-DRB4*0101-DQA1*0301-DQB1*0401 in Japanese patients (p &lt; 0.05); 3) increased frequency of the predicted haplotype DRB1*0803-DQA1*0103-DQB1*0601 in Chinese patients (p &lt; 0.05); and 4) no statistically significant association with DPB1 alleles in any group, although an increased number of Caucasoid and Japanese SS patients possessed DPB1*0301. Comparison of DNA sequences for the three disease-associated haplotypes in these ethnic groups revealed a shared region of predicted amino acids from positions 58 to 69 in the first domain of HLA-DQB1. These results extend previous studies by demonstrating that no single class II allele was associated with 1 degree SS in the different ethnic groups. However, a shared amino acid motif in the DQB1 first domain was present in each disease-associated haplotype.</jats:p>

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