Detailed analysis of failure patterns using deformable image registration in hypopharyngeal cancer patients treated with sequential boost intensity‐modulated radiotherapy
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- Manami Otsuka
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
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- Koichi Yasuda
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
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- Yusuke Uchinami
- Department of Radiation Oncology, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Nayuta Tsushima
- Department of Otolaryngology‐Head and Neck Surgery, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Takayoshi Suzuki
- Department of Otolaryngology‐Head and Neck Surgery, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Satoshi Kano
- Department of Otolaryngology‐Head and Neck Surgery, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Ryusuke Suzuki
- Department of Medical Physics Hokkaido University Hospital Sapporo Japan
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- Naoki Miyamoto
- Department of Medical Physics Hokkaido University Hospital Sapporo Japan
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- Hideki Minatogawa
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
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- Yasuhiro Dekura
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
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- Takashi Mori
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
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- Kentaro Nishioka
- Department of Radiation Medical Science and Engineering, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Jun Taguchi
- Department of Medical Oncology, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Yasushi Shimizu
- Department of Medical Oncology, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Norio Katoh
- Department of Radiation Oncology, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Akihiro Homma
- Department of Otolaryngology‐Head and Neck Surgery, Faculty and Graduate School of Medicine Hokkaido University Sapporo Japan
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- Hidefumi Aoyama
- Department of Radiation Oncology Hokkaido University Hospital Sapporo Japan
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Sequential boost intensity‐modulated radiotherapy (SQB‐IMRT) uses two different planning CTs (pCTs) and treatment plans. SQB‐IMRT is a form of adaptive radiotherapy that allows for responses to changes in the shape of the tumour and organs at risk (OAR). On the other hand, dose accumulation with the two plans can be difficult to evaluate. The purpose of this study was to analyse patterns of loco‐regional failure using deformable image registration (DIR) in hypopharyngeal cancer patients treated with SQB‐IMRT.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Between 2013 and 2019, 102 patients with hypopharyngeal cancer were treated with definitive SQB‐IMRT at our institution. Dose accumulation with the 1st and 2nd plans was performed, and the dose to the loco‐regional recurrent tumour volume was calculated using the DIR workflow. Failure was classified as follows: (i) in‐field (≥95% of the recurrent tumour volume received 95% of the prescribed dose); (ii) marginal (20–95%); or (iii) out‐of‐field (<20%).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After a median follow‐up period of 25 months, loco‐regional failure occurred in 34 patients. Dose–volume histogram analysis showed that all loco‐regional failures occurred in the field within 95% of the prescribed dose, with no marginal or out‐of‐field recurrences observed.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The dosimetric analysis using DIR showed that all loco‐regional failures were within the high‐dose region. More aggressive treatment may be required for gross tumours.</jats:p></jats:sec>
収録刊行物
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- Journal of Medical Imaging and Radiation Oncology
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Journal of Medical Imaging and Radiation Oncology 67 (1), 98-110, 2022-11-14
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360298755626593152
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- ISSN
- 17549485
- 17549477
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- データソース種別
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- Crossref
- KAKEN