Bubble dynamics and size distributions during focused ultrasound insonation

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  • Xinmai Yang
    National Center for Physical Acoustics, University of Mississippi, 1 Coliseum Drive, University, Mississippi 38677
  • Ronald A. Roy
    Department of Aerospace and Mechanical Engineering, Boston University, Boston, Massachusetts 02215
  • R. Glynn Holt
    Department of Aerospace and Mechanical Engineering, Boston University, Boston, Massachusetts 02215

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<jats:p>The deposition of ultrasonic energy in tissue can cause tissue damage due to local heating. For pressures above a critical threshold, cavitation will occur, inducing a much larger thermal energy deposition in a local region. The present work develops a nonlinear bubble dynamics model to numerically investigate bubble oscillations and bubble-enhanced heating during focused ultrasound (HIFU) insonation. The model is applied to calculate two threshold-dependent phenomena occurring for nonlinearly oscillating bubbles: Shape instability and growth by rectified diffusion. These instabilities in turn are shown to place physical boundaries on the time-dependent bubble size distribution, and thus the thermal energy deposition.</jats:p>

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