Ninety Years of Pentamidine: The Development and Applications of Pentamidine and its Analogs
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- Bo Zhang
- Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
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- Yushan Jin
- Faculty of Immunology and Department of Cell & Systems Biology, University of Toronto, Toronto, M5S 3G3, Canada
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- Lei Zhang
- Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
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- Hongshuang Wang
- Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
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- Xiaohui Wang
- Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
抄録
<jats:sec> <jats:title>Abstract:</jats:title> <jats:p>Pentamidine, an FDA-approved human drug for many protozoal infections, was initially synthesized in the late 1930s and first reported to be curative for parasitosis in the 1940s. After ninety years of sometimes quiet growth, pentamidine and its derivatives have gone far beyond antibacterial agents, including but not limited to the ligands of DNA minor groove, modulators of PPIs (protein-protein interactions) of the transmembrane domain 5 of lateral membrane protein 1, and the blockers of the SARS-CoV-2 3a channel. This mini-review highlights the development and applications of pentamidine and its analogs, aiming to provide insights for further developing pentamidine derivatives in the following decades.</jats:p> </jats:sec>
収録刊行物
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- Current Medicinal Chemistry
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Current Medicinal Chemistry 29 (26), 4602-4609, 2022-08
Bentham Science Publishers Ltd.