The neuropathic pain: An overview of the current treatment and future therapeutic approaches
-
- Eugenio Cavalli
- I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy
-
- Santa Mammana
- I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy
-
- Ferdinando Nicoletti
- Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
-
- Placido Bramanti
- I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy
-
- Emanuela Mazzon
- I.R.C.C.S. Centro Neurolesi Bonino Pulejo, Messina, Italy
説明
<jats:p> Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and the pathophysiological states that determine the onset of neuropathic pain are heterogeneous, such as metabolic disorders, neuropathy caused by viral infections, and autoimmune diseases affecting the central nervous system (CNS). Neuropathic pain in the general population is estimated to have a prevalence ranging between 3% and 17%. Most of the available treatments for neuropathic pain have moderate efficacy and present side effects that limit their use; therefore, other therapeutic approaches are needed for patients. In this article, the current standard of care treatment, the emerging pharmacological approaches from the completed phase III clinical trials, and the preclinical studies on novel promising therapeutic options will be reviewed. </jats:p>
収録刊行物
-
- International Journal of Immunopathology and Pharmacology
-
International Journal of Immunopathology and Pharmacology 33 205873841983838-, 2019-01
SAGE Publications