Each of 3,323 metabolic innovations in the evolution of <i>E. coli</i> arose through the horizontal transfer of a single DNA segment
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- Tin Yau Pang
- Institute for Computer Science, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany;
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- Martin J. Lercher
- Institute for Computer Science, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany;
抄録
<jats:title>Significance</jats:title> <jats:p> Bacteria often evolve by copying genes from other strains, a process termed horizontal gene transfer. As a consequence, different strains of the bacterial species <jats:italic>Escherichia coli</jats:italic> differ substantially in the sets of genes they possess. Here, we use the inferred gene sets of all recent ancestors of 53 <jats:italic>E. coli</jats:italic> strains to reconstruct the ancestors’ abilities to grow in different nutritional environments. This allows us to infer over 3,000 metabolic innovations in <jats:italic>E. coli</jats:italic> ’s evolutionary history. All innovations arose through the copying (transfer) of only one small piece of DNA from another strain, demonstrating an amazing capacity of <jats:italic>E. coli</jats:italic> to quickly adapt to new environments. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 116 (1), 187-192, 2018-12-18
Proceedings of the National Academy of Sciences